Target Name: Fibroblast Growth Factor Receptor (FGFR)
NCBI ID: P10960
Other Name(s): FGFR

FGFR: A Protein Target for Cancer and Neurodegenerative Diseases

Fibroblast Growth Factor Receptor (FGFR), also known as FGFR-1, is a protein that is expressed in a variety of tissues, including hair, skin, and bones. It plays a crucial role in cell signaling, particularly in the growth and development of tissues. FGFR has also been implicated in the development and progression of various diseases, including cancer. As a result, FGFR has become an attractive drug target for researchers and pharmaceutical companies.

FGFR is a transmembrane protein that is composed of four distinct tyrosine residues. It is expressed in a variety of tissues, including hair, skin, and bones. It is highly conserved, with significant sequence homogeneity across different species. FGFR has four known isoforms, FGFR1-4, which differ in their extracellular domain sequences and tissue-specific localization.

FGFR is involved in cell signaling, particularly in the growth and development of tissues. It plays a crucial role in the development and maintenance of tissues, including hair, skin, and bones. FGFR signaling is involved in the regulation of cell proliferation, differentiation, and survival. It is also involved in the regulation of cell-cell adhesion and tissue architecture.

FGFR has been implicated in the development and progression of various diseases, including cancer. For example, studies have shown that high levels of FGFR are associated with poor prognosis in patients with breast cancer. Additionally, FGFR has been shown to be involved in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

As a result, FGFR has become an attractive drug target for researchers and pharmaceutical companies. Many studies have identified potential FGFR inhibitors that could be used to treat various diseases. These inhibitors have been shown to be effective in preclinical studies, and further testing is being conducted to determine their safety and efficacy in clinical trials.

One of the most promising FGFR inhibitors is a small molecule called FAK inhibitor NB95-995. NB95-995 is a peptide that is derived from the tumor suppressor protein PDGF-BB. It is designed to selectively bind to FGFR and inhibit its activity. NB95-995 has been shown to be effective in preclinical studies in treating various diseases, including cancer.

Another promising FGFR inhibitor is a monoclonal antibody called AE302. AE302 is a humanized monoclonal antibody that is designed to selectively bind to FGFR and inhibit its activity. AE302 has been shown to be effective in preclinical studies in treating various diseases, including cancer.

In conclusion, FGFR is a protein that is involved in cell signaling and plays a crucial role in the development and maintenance of tissues. Its role in cell signaling is also involved in the regulation of various diseases, including cancer. As a result, FGFR has become an attractive drug target for researchers and pharmaceutical companies. Many studies have identified potential FGFR inhibitors that could be used to treat various diseases, including cancer. Further testing is being conducted to determine the safety and effectiveness of these inhibitors in clinical trials.

Protein Name: Fibroblast Growth Factor Receptor (FGFR) (nonspecified Subtype)

More Common Targets

Fibronectin Type III Domain | FICD | FIG4 | FIGLA | FIGN | FIGNL1 | FIGNL2 | FILIP1 | FILIP1L | FILNC1 | FIP1L1 | FIRRE | FIS1 | FITM1 | FITM2 | Five friends of methylated CHTOP complex | FIZ1 | FJX1 | FKBP10 | FKBP11 | FKBP14 | FKBP15 | FKBP1A | FKBP1A-SDCBP2 | FKBP1B | FKBP1C | FKBP2 | FKBP3 | FKBP4 | FKBP5 | FKBP6 | FKBP7 | FKBP8 | FKBP9 | FKBP9P1 | FKBPL | FKRP | FKSG29 | FKTN | FLACC1 | FLAD1 | FLCN | FLG | FLG-AS1 | FLG2 | FLI1 | FLII | FLJ12825 | FLJ13224 | FLJ16779 | FLJ20021 | FLJ20712 | FLJ25758 | FLJ30679 | FLJ31945 | FLJ32154 | FLJ32255 | FLJ33534 | FLJ36000 | FLJ37201 | FLJ37786 | FLJ38576 | FLJ39095 | FLJ40194 | FLJ42393 | FLJ42627 | FLJ42969 | FLJ43315 | FLJ44342 | FLJ44635 | FLJ45513 | FLJ46875 | FLNA | FLNB | FLNC | FLOT1 | FLOT2 | FLRT1 | FLRT2 | FLRT3 | FLT1 | FLT3 | FLT3LG | FLT4 | FLVCR1 | FLVCR1-DT | FLVCR2 | FLVCR2-AS1 | FLYWCH1 | FLYWCH2 | FMC1 | FMC1-LUC7L2 | FMN1 | FMN2 | FMNL1 | FMNL2 | FMNL3 | FMO1 | FMO2 | FMO3